Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2012

Sironi Manuela, Biasin Mara, Cagliani Rachele, Forni Diego, De Luca Mariacristina, Saulle Irma, Lo Caputo Sergio, Mazzotta Francesco, Macías Juan, Pineda Juan A, Caruz Antonio, Clerici Mario

Abstract excerpt

TLR3 recognizes dsRNA and activates antiviral immune responses through the production of inflammatory cytokines and type I IFNs. Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility. We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenylalanine
Share to Cohort Studies
Share to HIV Infections
Share to HIV Seronegativity
Share to Italy
Share to Leucine
Share to Spain
Share to Toll-Like Receptor 3

Source

Identifiers

PMID: 22174453
DOI: 10.4049/jimmunol.1102179

Genes

TLR3
CCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.PMID 22174453Read ↗

Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users.Semantic proximity Read ↗

Association of TLR3 single nucleotide polymorphisms with susceptibility to HTLV-1 infection in Iranian asymptomatic blood donors.Semantic proximity Read ↗

Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2 infection.Semantic proximity Read ↗

Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection - Differential influence in individuals with distinct ethnic background.Semantic proximity Read ↗

TLR3 Mutations in Adult Patients With Herpes Simplex Virus and Varicella-Zoster Virus Encephalitis.Semantic proximity Read ↗

A regulatory polymorphism in HAVCR2 modulates susceptibility to HIV-1 infection.Semantic proximity Read ↗

A real-time PCR assay for the simultaneous detection of functional N284I and L412F polymorphisms in the human Toll-like receptor 3 gene.Semantic proximity Read ↗

A functional toll-like receptor 8 variant is associated with HIV disease restriction.Semantic proximity Read ↗

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.Semantic proximity Read ↗

A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression.Semantic proximity Read ↗

The Relationship between TLR3 rs3775291 Polymorphism and Infectious Diseases: A Meta-Analysis of Case-Control Studies.Semantic proximity Read ↗

Strong Association of the rs4986790 Single Nucleotide Polymorphism (SNP) of the Toll-Like Receptor 4 (TLR4) Gene with Human Immunodeficiency Virus (HIV) Infection: A Meta-Analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.