Article
APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians.
AIDS (London, England) - 3 Oct 2006
Valcke Han Sang, Bernard Nicole F, Bruneau Julie, Alary Michel, Tsoukas Christos M, Roger Michel
Abstract excerpt
The cytosine deaminase APOBEC3G has been identified as a host factor that inhibits HIV-1 replication. We investigated whether genetic variants of APOBEC3G that could potentially affect the protein's expression or function were associated with the risk of infection in 122 Caucasians highly exposed to HIV-1. A novel C40693T variant was significantly associated with an increased risk of infection, suggesting that...
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