Article
A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.
The Journal of clinical investigation - 1 Mar 2011
Kim Hye Young, Eyheramonho María Belén, Pichavant Muriel, Gonzalez Cambaceres Carlos, Matangkasombut Ponpan, Cervio Guillermo, Kuperman Silvina, Moreiro Rita, Konduru Krishnamurthy, Manangeeswaran Mohanraj, Freeman Gordon J, Kaplan Gerardo G, DeKruyff Rosemarie H, Umetsu Dale T, Rosenzweig Sergio D
Abstract excerpt
During infection with the hepatitis A virus (HAV), most patients develop mild or asymptomatic disease. However, a small number of patients develop serious, life-threatening hepatitis. We investigated this variability in disease severity by examining 30 Argentinean patients with HAV-induced acute liver failure in a case-control, cross-sectional, observational study. We found that HAV-induced severe liver disease...
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