Functional analyses reveal extensive RRE plasticity in primary HIV-1 sequences selected under selective pressure.

doi:10.1371/journal.pone.0106299

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Article

Functional analyses reveal extensive RRE plasticity in primary HIV-1 sequences selected under selective pressure.

PloS one - 1 Jan 2014

Cunyat Francesc, Beerens Nancy, García Elisabet, Clotet Bonaventura, Kjems Jørgen, Cabrera Cecilia

Abstract excerpt

BACKGROUND: HIV-1 Rev response element (RRE) is a functional region of viral RNA lying immediately downstream to the junction of gp120 and gp41 in the env coding sequence. The RRE is essential for HIV replication and binds with the Rev protein to facilitate the export of viral mRNA from nucleus to cytoplasm. It has been suggested that changes in the predicted secondary structure of primary RRE sequences impact...

Topics

Cell Line
Evolution, Molecular
Female
Genes, env
HIV-1
Humans
Male
Mutation
RNA, Messenger
RNA, Viral
Selection, Genetic
Virus Replication
rev Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 25170621
DOI: 10.1371/journal.pone.0106299
PMCID: PMC4149556

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