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Article

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.

Nucleic acids research - 19 May 2015

Sherpa Chringma, Rausch Jason W, Le Grice Stuart F J, Hammarskjold Marie-Louise, Rekosh David

Abstract excerpt

The HIV Rev protein forms a complex with a 351 nucleotide sequence present in unspliced and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the Rev response element (RRE), to recruit the cellular nuclear export receptor Crm1 and Ran-GTP. This complex facilitates nucleo-cytoplasmic export of these mRNAs. The precise secondary structure of the HIV-1 RRE has been controversial, since studies have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Regulatory Sequences, Ribonucleic Acid

Share to rev Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 25855816
DOI: 10.1093/nar/gkv313
PMCID: PMC4482075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.PMID 25855816Read ↗

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