Article

Evolution of the HIV-1 RRE during natural infection reveals nucleotide changes that correlate with altered structure and increased activity over time

2018-12-04

Abstract excerpt

<h4>ABSTRACT</h4> The HIV-1 Rev Response Element (RRE) is a cis -acting RNA element characterized by multiple stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promotes nucleocytoplasmic export of incompletely spliced mRNAs, an essential step in HIV replication. Most of our understanding of the Rev-RRE regulatory axis comes from studies of lab-adapted HIV clones. However, in human infecti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1277f4e8-a6c4-5a8e-a54b-6f9645122359
DOI: 10.1101/483511

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution of the HIV-1 RRE during natural infection reveals nucleotide changes that correlate with altered structure and increased activity over timeDOI 10.1101/483511Read

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.Semantic proximity Read

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read

Rev-RRE Functional Activity Differs Substantially Among Primary HIV-1 Isolates.Semantic proximity Read

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.Semantic proximity Read

Two secondary structures for the RRE of HIV-1?Semantic proximity Read

Functional analyses reveal extensive RRE plasticity in primary HIV-1 sequences selected under selective pressure.Semantic proximity Read

Heterogeneity of HIV-1 Rev response element.Semantic proximity Read

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Semantic proximity Read

Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction.Semantic proximity Read

HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latencySemantic proximity Read

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.Semantic proximity Read

Evidence of a Direct Evolutionary Selection for Strong Folding and Mutational Robustness Within HIV Coding Regions.Semantic proximity Read