Article
Treatment with the fusion inhibitor enfuvirtide influences the appearance of mutations in the human immunodeficiency virus type 1 regulatory protein rev.
Antimicrobial agents and chemotherapy - 1 Jul 2009
Svicher Valentina, Alteri Claudia, D'Arrigo Roberta, Laganà Alessandro, Trignetti Maria, Lo Caputo Sergio, Callegaro Anna Paola, Maggiolo Franco, Mazzotta Francesco, Ferro Alfredo, Dimonte Salvatore, Aquaro Stefano, di Perri Giovanni, Bonora Stefano, Tommasi Chiara, Trotta Maria Paola, Narciso Pasquale, Antinori Andrea, Perno Carlo Federico, Ceccherini-Silberstein Francesca
Abstract excerpt
The gp41-encoding sequence of the env gene contains in two separate regions the Rev-responsive elements (RRE) and the alternative open reading frame of the second exon of the regulatory protein Rev. The binding of Rev to the RRE allows the transport of unspliced/singly spliced viral mRNAs out of...
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