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Article

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.

Science (New York, N.Y.) - 16 Feb 1990

Olsen H S, Nelbock P, Cochrane A W, Rosen C A

Abstract excerpt

A region in the human immunodeficiency virus (HIV) env message, with the potential to form a complex secondary structure (designated RRE), interacts with the rev protein (Rev). This interaction is believed to mediate export of HIV structural messenger RNAs from the nucleus to the cytoplasm. In this report the regions essential for Rev interaction with the RRE are further characterized and the functional...

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Identifiers

PMID: 2406903
DOI: 10.1126/science.2406903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Secondary structure is the major determinant for interaction of HIV rev protein with RNA.PMID 2406903Read ↗

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structureSemantic proximity Read ↗

Mutational analysis of the HIV-1 Rev protein and its target sequence, the Rev responsive element.Semantic proximity Read ↗

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read ↗

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.Semantic proximity Read ↗

Two secondary structures for the RRE of HIV-1?Semantic proximity Read ↗

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.Semantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Functional analyses reveal extensive RRE plasticity in primary HIV-1 sequences selected under selective pressure.Semantic proximity Read ↗

Heterogeneity of HIV-1 Rev response element.Semantic proximity Read ↗

Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction.Semantic proximity Read ↗

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.Semantic proximity Read ↗

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.Semantic proximity Read ↗

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