Article
Secondary structure is the major determinant for interaction of HIV rev protein with RNA.
Science (New York, N.Y.) - 16 Feb 1990
Olsen H S, Nelbock P, Cochrane A W, Rosen C A
Abstract excerpt
A region in the human immunodeficiency virus (HIV) env message, with the potential to form a complex secondary structure (designated RRE), interacts with the rev protein (Rev). This interaction is believed to mediate export of HIV structural messenger RNAs from the nucleus to the cytoplasm. In this report the regions essential for Rev interaction with the RRE are further characterized and the functional...
Topics
- Base Composition
- Base Sequence
- Chromosome Deletion
- Gene Products, rev
- Genes, rev
- HIV
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Protein Conformation