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Article

Mutational analysis of the HIV-1 Rev protein and its target sequence, the Rev responsive element.

Journal of acquired immune deficiency syndromes - 1 Jan 1991

Olsen H S, Beidas S, Dillon P, Rosen C A, Cochrane A W

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Rev protein is a positive posttranscriptional regulator of viral structural gene expression and essential for virus replication. Rev mediates its effects through interaction with an RNA target sequence, the Rev responsive element (RRE), present within the env mRNA. Previous studies have shown that the basic stretch of amino acids are required for Rev's ability to...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
DNA Mutational Analysis
Gene Products, rev
Genes, env
Genes, rev
HIV-1
HIV-2
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nucleic Acid Conformation

RNA, Viral

Simian Immunodeficiency Virus

rev Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 2023097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2023097-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutational analysis of the HIV-1 Rev protein and its target sequence, the Rev responsive element.PMID 2023097Read ↗

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structureSemantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Semantic proximity Read ↗

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.Semantic proximity Read ↗

Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotype.Semantic proximity Read ↗

Mutational analysis of functional domains in the HIV-1 Rev trans-regulatory protein.Semantic proximity Read ↗

Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminusSemantic proximity Read ↗

Real-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysis.Semantic proximity Read ↗

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read ↗

Deletions near the N-terminus of HIV-1 Rev reduce RNA binding affinity and dominantly interfere with Rev function irrespective of the RNA target.Semantic proximity Read ↗

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.Semantic proximity Read ↗

Specific binding of a basic peptide from HIV-1 Rev.Semantic proximity Read ↗

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