Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.

Journal of virology - 1 Oct 2013

Sloan Emily A, Kearney Mary F, Gray Laurie R, Anastos Kathryn, Daar Eric S, Margolick Joseph, Maldarelli Frank, Hammarskjold Marie-Louise, Rekosh David

Abstract excerpt

HIV-1 Rev and the Rev response element (RRE) enable a critical step in the viral replication cycle by facilitating the nuclear export of intron-containing mRNAs, yet their activities have rarely been analyzed in natural infections. This study characterized their genetic and functional variation in a small cohort of HIV-infected individuals. Multiple Rev and RRE sequences were obtained using single-genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to Genes, env

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Infections

Share to Plasma

Share to rev Gene Products, Human Immunodeficiency Virus

Share to RNA, Viral

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 23926352
DOI: 10.1128/JVI.01392-13
PMCID: PMC3807272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.PMID 23926352Read ↗

Rev-RRE Functional Activity Differs Substantially Among Primary HIV-1 Isolates.Semantic proximity Read ↗

Evolution of the HIV-1 RRE during natural infection reveals nucleotide changes that correlate with altered structure and increased activity over timeSemantic proximity Read ↗

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.Semantic proximity Read ↗

HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latencySemantic proximity Read ↗

Functional analyses reveal extensive RRE plasticity in primary HIV-1 sequences selected under selective pressure.Semantic proximity Read ↗

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.Semantic proximity Read ↗

HIV Rev Assembly on the Rev Response Element (RRE): A Structural PerspectiveSemantic proximity Read ↗

Real-time kinetics of HIV-1 Rev-Rev response element interactions. Definition of minimal binding sites on RNA and protein and stoichiometric analysis.Semantic proximity Read ↗

Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Semantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Heterogeneity of HIV-1 Rev response element.Semantic proximity Read ↗

Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.