Article
Rev-RRE Functional Activity Differs Substantially Among Primary HIV-1 Isolates.
AIDS research and human retroviruses - 1 Sept 2016
Jackson Patrick E, Tebit Denis M, Rekosh David, Hammarskjold Marie-Louise
Abstract excerpt
The HIV-1 replication cycle requires the nucleocytoplasmic export of intron-containing viral RNAs, a process that is ordinarily restricted. HIV overcomes this by means of the viral Rev protein, which binds to an RNA secondary structure called the Rev response element (RRE) present in all unspliced or incompletely spliced viral RNA transcripts. The resulting mRNP complex is exported through interaction with...
Topics
- Biological Variation, Population
- Genes, env
- Genetic Variation
- HIV Infections
- HIV-1
- Humans
- Protein Binding
- Virus Replication
- rev Gene Products, Human Immunodeficiency Virus