Article
Cytochrome P450 2D6*10 genotype affects the pharmacokinetics of dimemorfan in healthy Chinese subjects.
European journal of drug metabolism and pharmacokinetics - 1 Dec 2015
Pei Qi, Peng Jinfu, Tan Hongyi, Yang Liu, Yang Xiding, Liu Li, Liu Shikun, Yuan Hong, Yang Guoping
Abstract excerpt
This study aimed to investigate the effects of cytochrome P450 2D6*10 (100C > T, rs1065852) genotype on the pharmacokinetics of dimemorfan in healthy Chinese subjects. Data were evaluated from 24 subjects in two pharmacokinetic studies who received an oral dose of 40 mg of dimemorfan syrup (n = 12) or dimemorfan tablet (n = 12) after providing written informed consent and being divided into three groups: subjects...
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