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Article

Effects of CYP2D6 10 and 41 Variants in Healthy Chinese Men on the Pharmacokinetics of Dapoxetine.

Journal of clinical pharmacology - 1 May 2024

Wang Zhipeng, Gao Yuan, Ji Xingfang, Wu Tong, Pu Libin, Qiu Wen

Abstract excerpt

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat premature ejaculation (PE), and is mainly metabolized by CYP2D6, CYP3A4, and flavin-containing monooxygenase 1. The purpose of the study was to evaluate the effect of CYP2D6 polymorphism on the pharmacokinetics of dapoxetine in healthy Chinese men. Thirty-nine subjects who received a single oral dose of 30 mg dapoxetine hydrochloride were...

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Source

Identifiers

PMID: 38059315
DOI: 10.1002/jcph.2391

Genes

CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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