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Article

Pharmacokinetics, safety, and tolerability of atomoxetine and effect of CYP2D610/10 genotype in healthy Japanese men.

Journal of clinical pharmacology - 1 Mar 2012

Matsui A, Azuma J, Witcher J W, Long A J, Sauer J-M, Smith B P, DeSante K A, Read H A, Takahashi M, Nakano M

Abstract excerpt

Atomoxetine is a cytochrome P4502D6 (CYP2D6) substrate. The reduced-activity CYP2D6*10 allele is particularly prevalent in the Japanese population and may contribute to known ethnic differences in CYP2D6 metabolic capacity. The purpose of this study was to examine atomoxetine pharmacokinetics, safety, tolerability, and the effect of the CYP2D6*10/*10 genotype after single-stepped dosing (10, 40, 90, or 120 mg)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21543662
DOI: 10.1177/0091270011398657

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