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Article

Effects of the Chinese herbal formula "Zuojin Pill" on the pharmacokinetics of dextromethorphan in healthy Chinese volunteers with CYP2D6*10 genotype.

European journal of clinical pharmacology - 1 Jun 2016

Qiu Furong, Liu Songcan, Miao Ping, Zeng Jin, Zhu Leilei, Zhao TongFang, Ye Yujie, Jiang Jian

Abstract excerpt

OBJECTIVE: Zuojin Pill has been shown to inhibit the cytochrome P450 (CYP) 2D6 isoenzyme in vitro. In Chinese individuals, CYP 2D6*10 is the most common allele with reduced enzyme activity. In this study, we investigated the pharmacokinetic interaction between Zuojin Pill and the sensitive CYP2D6 probe dextromethorphan in healthy Chinese volunteers with CYP2D6*10 genotype. METHODS: A pharmacokinetics interaction...

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Identifiers

PMID: 27023460
DOI: 10.1007/s00228-016-2048-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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