Article
Effects of the CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites.
Archives of pharmacal research - 1 Nov 2015
Byeon Ji-Yeong, Kim Young-Hoon, Na Han-Sung, Jang Jong-Hwa, Kim Se-Hyung, Lee Yun-Jeong, Bae Jung-Woo, Kim In Su, Jang Choon-Gon, Chung Myeon-Woo, Lee Seok-Yong
Abstract excerpt
To investigate the effect of the variant CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites, 4-hydroxyatomoxetine (4-HAT) and N-desmethylatomoxetine (NAT), in healthy subjects, a single oral dose of atomoxetine was administered to 62 subjects with a CYP2D6*wt/*wt (*wt = *1 or *2, n = 22), CYP2D6*wt/*10 (n = 22) or CYP2D6*10/*10 (n = 18) genotype. Plasma samples were then collected for...
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