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Article

Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

The Journal of biological chemistry - 24 Oct 2014

Liu Li, Trent Chad M, Fang Xiang, Son Ni-Huiping, Jiang HongFeng, Blaner William S, Hu Yunying, Yin Yu-Xin, Farese Robert V, Homma Shunichi, Turnbull Andrew V, Eriksson Jan W, Hu Shi-Lian, Ginsberg Henry N, Huang Li-Shin, Goldberg Ira J

Abstract excerpt

Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the final step in triglyceride synthesis, the conversion of diacylglycerol (DAG) to triglyceride. Dgat1(-/-) mice exhibit a number of beneficial metabolic effects including reduced obesity and improved insulin sensitivity and no known cardiac dysfunction. In contrast, failing human hearts have severely reduced DGAT1 expression associated with accumulation of DAGs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25157099
DOI: 10.1074/jbc.M114.601864
PMCID: PMC4207999

Genes

DGAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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