Article

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

2024-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart disease are poorly understood and it is a condition for which there are no targeted therapies. Recently, disrupted glycogen-autophagy (glycophagy) and glycogen accumulation have been identified in the diabetic heart. Glycophagy involves glycog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd553d8c-52e2-5445-bd3d-57a8d0e23bc1
DOI: 10.1101/2024.11.28.625926

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissuesDOI 10.1101/2024.11.28.625926Read

Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart diseaseSemantic proximity Read

Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic CardiomyopathySemantic proximity Read

The glycogen cargo receptor STBD1: from biology to disease targeted therapiesSemantic proximity Read

Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathySemantic proximity Read

ATG4D loss leads to late-onset cardiomyopathy and stress-induced heart failure in mice, and its repression marks maladaptive cardiac remodeling in humansSemantic proximity Read

CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunctionSemantic proximity Read

The role of autophagy in the pathogenesis of glycogen storage disease type II (GSDII)Semantic proximity Read

Mitophagy in Diabetic Cardiomyopathy: Roles and MechanismsSemantic proximity Read

Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heartSemantic proximity Read

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological StrategiesSemantic proximity Read

Multi-omics reveals lipid metabolism, mitochondrial and extracellular matrix dysregulation of diabetic cardiomyopathy in the human heartSemantic proximity Read

Autophagy–Lysosomal Dysfunction as a Converging Mechanism of Cardiomyopathy in Lysosomal Storage Disorders: From Pathobiology to Targeted TherapySemantic proximity Read