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Article

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Diabetes - 1 Jun 2018

Rohm Maria, Savic Dragana, Ball Vicky, Curtis M Kate, Bonham Sarah, Fischer Roman, Legrave Nathalie, MacRae James I, Tyler Damian J, Ashcroft Frances M

Abstract excerpt

Diabetes is a well-established risk factor for heart disease, leading to impaired cardiac function and a metabolic switch toward fatty acid usage. In this study, we investigated if hyperglycemia/hypoinsulinemia in the absence of dyslipidemia is sufficient to drive these changes and if they can be reversed by restoring euglycemia. Using the βV59M mouse model, in which diabetes can be rapidly induced and reversed,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29610263
DOI: 10.2337/db17-1195

Genes

PDK4
UCP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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