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Article

No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients.

Basic & clinical pharmacology & toxicology - 1 Jan 2022

Kuhlmann Ida, Hjelmar Petersen Rasmus, Overgaard Morten, Dornonville de la Cour Kenn, Zwisler Stine, Bjerregaard Stage Tore, Hougaard Christensen Mette Marie, Bergmann Troels K, Damkier Per, Gadegaard Jensen Anders, Nielsen Flemming, Brøsen Kim

Abstract excerpt

We investigated the impact of genetic variants in OCT1 (SLC22A1) on morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) pharmacokinetics in adult patients scheduled for major surgery. Blood samples were taken before and 5, 10, 15, 30, 45, 60 and 90 min after a bolus of morphine (0.15 mg/kg). Patients were genotyped for the genetic variants (rs12208357, rs34059508, rs72552763 and rs34130495) in...

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Share to Aged
Share to Analgesics, Opioid
Share to Area Under Curve
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Share to Octamer Transcription Factor-1
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Identifiers

PMID: 34599645
DOI: 10.1111/bcpt.13667
PMCID: PMC9298338

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