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Article

Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Mar 2017

Nielsen L M, Sverrisdóttir E, Stage T B, Feddersen S, Brøsen K, Christrup L L, Drewes A M, Olesen A E

Abstract excerpt

AIM: A high inter-individual variation in the pharmacokinetics and pharmacodynamics of morphine has been observed. Genetic polymorphisms in genes encoding the organic cation transporter isoform 1 (OCT1), the efflux transporter p-glycoprotein (ABCB1), and the UDP-glucuronosyltransferase-2B7 (UGT2B7) may influence morphine pharmacokinetics and thus, also pharmacodynamics. The aim of this study was to evaluate the...

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Identifiers

PMID: 28063968
DOI: 10.1016/j.ejps.2016.12.039

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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