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Article

Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population.

Clinical pharmacology and therapeutics - 1 Apr 2022

Williams Michael L, Kannankeril Prince J, Breeyear Joseph H, Edwards Todd L, Van Driest Sara L, Choi Leena

Abstract excerpt

Fentanyl is an anesthetic/analgesic commonly used in surgical and recovery settings. CYP3A4 and CYP3A5 encode enzymes, which metabolize fentanyl; genetic variants in these genes impact fentanyl pharmacokinetics in adults. Pharmacokinetic (PK) studies are difficult to replicate in children due to the burden of additional blood taken solely for research purposes. The aim of this study is to test the effect of...

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Alleles
Cohort Studies
Cytochrome P-450 CYP3A
Fentanyl
Genotype

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PMID: 34877660
DOI: 10.1002/cpt.2506
PMCID: PMC8940650

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