Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients.

doi:10.1002/jcph.1592

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Article

Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients.

Journal of clinical pharmacology - 1 Aug 2020

Hahn David, Fukuda Tsuyoshi, Euteneuer Joshua C, Mizuno Tomoyuki, Vinks Alexander A, Sadhasivam Senthilkumar, Emoto Chie

Abstract excerpt

We have previously reported the influences of OCT1 ontogeny and genetic variation on morphine clearance in neonatal and pediatric patients. In the latter study, plasma morphine-glucuronide levels correlated with patient genotype for the rs4793665 single-nucleotide polymorphism (SNP) at the locus of MRP3, an efflux transporter of morphine glucuronides between hepatocytes and circulating blood. The link between...

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PMID: 32090339
DOI: 10.1002/jcph.1592

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