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Article

OCT1 pharmacogenetics in pain management: is a clinical application within reach?

Pharmacogenomics - 1 Nov 2017

Tzvetkov Mladen V

Abstract excerpt

Beside drug metabolizing enzymes alsogenetically variable membrane transporters may substantially contribute to the interindividual variability in pharmacokinetics and efficacy of opioids and other analgesics. The organic cation transporter OCT1 is strongly expressed in the sinusoidal membrane of the human liver. It may affect hepatic uptake and thus limit metabolic rates. OCT1 is highly genetically variable....

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Share to Analgesics, Opioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 29061087
DOI: 10.2217/pgs-2017-0095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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