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Article

OCT1 genetic variants influence the pharmacokinetics of morphine in children.

Pharmacogenomics - 1 Jul 2013

Fukuda Tsuyoshi, Chidambaran Vidya, Mizuno Tomoyuki, Venkatasubramanian Raja, Ngamprasertwong Pornswan, Olbrecht Vanessa, Esslinger Hope R, Vinks Alexander A, Sadhasivam Senthilkumar

Abstract excerpt

AIM: Large interindividual variability in morphine disposition could contribute to unpredictable variability in morphine analgesia and adverse events. Caucasian children have more adverse effects and slower morphine clearance than African-American children. To study variations in intravenous morphine pharmacokinetics in children, we examined the influence of genetic polymorphisms in OCT1. METHODS: In 146 children...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23859569
DOI: 10.2217/pgs.13.94
PMCID: PMC4116670

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