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Article

Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese.

Archives of general psychiatry - 1 Sept 2007

Lin Yi-Mei J, Chao Shin-Chih, Chen Tsung-Ming, Lai Te-Jen, Chen Jia-Shing, Sun H Sunny

Abstract excerpt

CONTEXT: The tryptophan hydroxylase 2 (TPH2) gene encodes the first (also the rate-limiting) enzyme in the serotonin biosynthetic pathway. Despite reports of possible associations between polymorphisms in human TPH2 and many psychiatric disorders, including bipolar disorder (BPD), the functional effect and susceptibility loci of such polymorphisms for BPD have not yet been identified. OBJECTIVES: To examine the...

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Source

Identifiers

PMID: 17768266
DOI: 10.1001/archpsyc.64.9.1015

Genes

TPH2
TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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