Article
Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.
Immunobiology - 1 Feb 2015
Kreiser Simon, Eckhardt Jenny, Kuhnt Christine, Stein Marcello, Krzyzak Lena, Seitz Christine, Tucher Christine, Knippertz Ilka, Becker Christoph, Günther Claudia, Steinkasserer Alexander, Lechmann Matthias
Abstract excerpt
The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphocyte antigen-4 (CTLA-4), glucocorticoid-induced TNFR family-related gene (GITR), Helios and...
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