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Article

tTregs, pTregs, and iTregs: similarities and differences.

Immunological reviews - 1 May 2014

Shevach Ethan M, Thornton Angela M

Abstract excerpt

Foxp3(+) T-regulatory cells (Tregs) are primarily generated in the thymus (tTreg), but also may be generated extrathymically at peripheral sites (pTreg), or induced in cell culture (iTreg) in the presence of transforming growth factor β (TGFβ). A major unresolved issue is how these different populations of Tregs exert their suppressive function in vivo. We have developed novel systems in which the function of...

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Identifiers

PMID: 24712461
DOI: 10.1111/imr.12160
PMCID: PMC3982187

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