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Article

Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.

Frontiers in immunology - 1 Jan 2023

Peckert-Maier Katrin, Wild Andreas B, Sprißler Laura, Fuchs Maximilian, Beck Philipp, Auger Jean-Philippe, Sinner Pia, Strack Astrid, Mühl-Zürbes Petra, Ramadan Ntilek, Kunz Meik, Krönke Gerhard, Stich Lena, Steinkasserer Alexander, Royzman Dmytro

Abstract excerpt

Alterations in macrophage (Mφ) polarization, function, and metabolic signature can foster development of chronic diseases, such as autoimmunity or fibrotic tissue remodeling. Thus, identification of novel therapeutic agents that modulate human Mφ biology is crucial for treatment of such conditions. Herein, we demonstrate that the soluble CD83 (sCD83) protein induces pro-resolving features in human...

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Identifiers

PMID: 38162675
DOI: 10.3389/fimmu.2023.1293828
PMCID: PMC10755915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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