Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Nov 2010

Dwyer K M, Hanidziar D, Putheti P, Hill P A, Pommey S, McRae J L, Winterhalter A, Doherty G, Deaglio S, Koulmanda M, Gao W, Robson S C, Strom T B

Abstract excerpt

We have shown that CD39 and CD73 are coexpressed on the surface of murine CD4+ Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg immunosuppressive activity. We now describe that CD39, independently of CD73, is expressed by a subset of blood-derived human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apyrase
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft Rejection

Share to Immunologic Memory

Share to Interleukin-17

Share to Interleukin-2 Receptor alpha Subunit

Share to Pyrophosphatases

Share to Th17 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 20977632
DOI: 10.1111/j.1600-6143.2010.03291.x
PMCID: PMC2966025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20977632-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype.PMID 20977632Read ↗

Evaluation of CD4+ CD25+/- CD39+ T-cell populations in peripheral blood of patients following kidney transplantation and during acute allograft rejection.Semantic proximity Read ↗

Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets.Semantic proximity Read ↗

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation.Semantic proximity Read ↗

TCR usage, gene expression and function of two distinct FOXP3(+)Treg subsets within CD4(+)CD25(hi) T cells identified by expression of CD39 and CD45RO.Semantic proximity Read ↗

Human CD39+ Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism.Semantic proximity Read ↗

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes.Semantic proximity Read ↗

IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis.Semantic proximity Read ↗

CD39 positive regulatory T cell frequency as a biomarker of treatment response to methotrexate in rheumatoid arthritis.Semantic proximity Read ↗

Phenotypical analysis of ectoenzymes CD39/CD73 and adenosine receptor 2A in CD4+ CD25high Foxp3+ regulatory T-cells in psoriasis.Semantic proximity Read ↗

Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity.Semantic proximity Read ↗

Hiding in Plain Sight: CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissuesSemantic proximity Read ↗

Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.