Article
A novel mutation in CD83 results in the development of a unique population of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2004
García-Martínez Leon F, Appleby Mark W, Staehling-Hampton Karen, Andrews Dawn M, Chen Yuching, McEuen Mark, Tang Phuong, Rhinehart Rebecca L, Proll Sean, Paeper Bryan, Brunkow Mary E, Grandea Andres G, Howard Edward D, Walker Don E, Charmley Patrick, Jonas Mechthild, Shaw Stevan, Latham John A, Ramsdell Fred
Abstract excerpt
Using a mouse mutagenesis screen, we have identified CD83 as being critical for the development of CD4(+) T cells and for their function postactivation. CD11c(+) dendritic cells develop and function normally in mice with a mutated CD83 gene but CD4(+) T cell development is substantially reduced....
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