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Article

IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015

Yuan Xiaomei, Dee Michael J, Altman Norman H, Malek Thomas R

Abstract excerpt

A network of mechanisms operates to maintain tolerance in the gut mucosa. Although CD103 marks many lymphoid cells within the gut, its direct functional role in intestinal tolerance is poorly understood. CD103 may be part of a redundant pathway, as CD103(-/-) mice do not exhibit autoimmunity. To reduce such redundancy, CD103(-/-) mice were crossed to mice (designated Y3) whose T cells expressed a mutant...

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Identifiers

PMID: 25527788
DOI: 10.4049/jimmunol.1400955
PMCID: PMC4297734

Genes

CCR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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