Article
Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells.
Journal of molecular cell biology - 1 Feb 2014
Liu Ya, Lan Qin, Lu Ling, Chen Maogen, Xia Zanxian, Ma Jilin, Wang Julie, Fan Huimin, Shen Yi, Ryffel Bernhard, Brand David, Quismorio Francisco, Liu Zhongmin, Horwitz David A, Xu Anping, Zheng Song Guo
Abstract excerpt
TGF-β and Foxp3 expressions are crucial for the induction and functional activity of CD4(+)Foxp3(+) regulatory T (iTreg) cells. Here, we demonstrate that although TGF-β-primed CD8(+) cells display much lower Foxp3 expression, their suppressive capacity is equivalent to that of CD4(+) iTreg cells, and both Foxp3(-) and Foxp3(+) CD8+ subsets have suppressive activities in vitro and in vivo. CD8(+)Foxp3(-) iTreg...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.