Article
CD83 is a dimer: Comparative analysis of monomeric and dimeric isoforms.
Biochemical and biophysical research communications - 1 Apr 2005
Lechmann Matthias, Kotzor Nicole, Zinser Elisabeth, Prechtel Alexander T, Sticht Heinrich, Steinkasserer Alexander
Abstract excerpt
Recently, we reported that soluble CD83 has a strong immunosuppressive activity in vitro as well as in vivo. Sequence alignment of CD83 between different species revealed the presence of five cysteines in the extracellular Ig-domain of the protein. This opens up the possibility that four cysteines are involved in the formation of two intramolecular disulfide bonds and a possible involvement of the remaining fifth...
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