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4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus

3 Mar 2016

Abstract excerpt

Genome-wide association studies (GWAS) have identified >100 independent susceptibility loci for prostate cancer, including the hot spot at 8q24. However, how genetic variants at this locus confer disease risk hasn't been fully characterized. Using circularized chromosome conformation capture (4C) coupled with next-generation sequencing and an enhancer at 8q24 as "bait", we identified genome-wide partners...

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PMID: 26934861
DOI: 10.1038/srep22462

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