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Article

Prostate Cancer Transcriptomic Regulation by the Interplay of Germline Risk Alleles, Somatic Mutations, and 3D Genomic Architecture.

Cancer discovery - 2 Dec 2022

Yuan Jiapei, Houlahan Kathleen E, Ramanand Susmita G, Lee Sora, Baek GuemHee, Yang Yang, Chen Yong, Strand Douglas W, Zhang Michael Q, Boutros Paul C, Mani Ram S

Abstract excerpt

Prostate cancer is one of the most heritable human cancers. Genome-wide association studies have identified at least 185 prostate cancer germline risk alleles, most noncoding. We used integrative three-dimensional (3D) spatial genomics to identify the chromatin interaction targets of 45 prostate cancer risk alleles, 31 of which were associated with the transcriptional regulation of target genes in 565 localized...

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Identifiers

PMID: 36108240
DOI: 10.1158/2159-8290.CD-22-0027
PMCID: PMC9722594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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