Article
Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.
British journal of cancer - 23 May 2017
Barry Kathryn Hughes, Moore Lee E, Sampson Joshua N, Koutros Stella, Yan Liying, Meyer Ann, Reddy Mahitha, Oler Andrew J, Cook Michael B, Fraumeni Joseph F, Yeager Meredith, Amundadottir Laufey T, Berndt Sonja I
Abstract excerpt
BACKGROUND: Chromosome 8q24 has emerged as an important genetic susceptibility region for several cancers, including prostate cancer; however, little is known about the contribution of DNA methylation in this region to risk. METHODS: We prospectively evaluated DNA methylation at 8q24 in relation to prostate cancer using pre-diagnostic blood samples from 694 prostate cancer cases (including 172 aggressive cases)...
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