Article
Potassium channel silencing by constitutive endocytosis and intracellular sequestration.
The Journal of biological chemistry - 12 Feb 2010
Feliciangeli Sylvain, Tardy Magalie P, Sandoz Guillaume, Chatelain Franck C, Warth Richard, Barhanin Jacques, Bendahhou Saïd, Lesage Florian
Abstract excerpt
Tandem of P domains in a weak inwardly rectifying K(+) channel 1 (TWIK1) is a K(+) channel that produces unusually low levels of current. Replacement of lysine 274 by a glutamic acid (K274E) is associated with stronger currents. This mutation would prevent conjugation of a small ubiquitin modifier peptide to Lys-274, a mechanism proposed to be responsible for channel silencing. However, we found no biochemical...
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