Article
Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.
ACS chemical neuroscience - 15 Mar 2017
Dadi Prasanna K, Vierra Nicholas C, Days Emily, Dickerson Matthew T, Vinson Paige N, Weaver C David, Jacobson David A
Abstract excerpt
The two-pore-domain potassium (K2P) channel TREK-2 serves to modulate plasma membrane potential in dorsal root ganglia c-fiber nociceptors, which tunes electrical excitability and nociception. Thus, TREK-2 channels are considered a potential therapeutic target for treating pain; however, there are currently no selective pharmacological tools for TREK-2 channels. Here we report the identification of the first...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.