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Article

Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.

The Journal of biological chemistry - 15 Nov 2002

Scholze Petra, Freissmuth Michael, Sitte Harald H

Abstract excerpt

Na(+)/Cl(-)-dependent neurotransmitter transporters form constitutive oligomers, the significance of which is not known. In soluble proteins, leucine heptad repeats drive dimerization; the rat gamma-aminobutyric acid transporter GAT-1 (rGAT) contains a motif reminiscent of a leucine heptad repeat in the second transmembrane helix (TM2). We substituted leucine residues in TM2 of rGAT by alanine and tested the...

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Identifiers

PMID: 12223478
DOI: 10.1074/jbc.M205602200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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