Article

Epileptic encephalopathy-related Kv2.1 mutants impair channel clustering and membrane distribution but not neuronal excitability

2025-10-14

Abstract excerpt

The voltage-gated potassium channel Kv2.1, which is encoded by the epileptic encephalopathy-associated gene KCNB1 , is a primary driver of delayed-rectifier K + currents in neurons. These currents contribute to high frequency firing by preventing depolarization block due to Na + channel inactivation. Wild-type (WT) channels are localized at the soma, proximal dendrites and axons, forming large aggregates (clust...

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Literature Corpus work: c6c36664-f2f8-54d4-83fa-a6c493849277
DOI: 10.1101/2025.10.13.681825

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