Article

An ER retention motif controls the heteromeric stoichiometry of hERG1a/1b channels

2026-02-20

Abstract excerpt

The human ether-à-go-go related gene ( hERG ) encodes a potassium channel essential for cardiac repolarization and neuronal excitability. In the heart, heteromeric assemblies of hERG1a and hERG1b subunits produce cardiac I Kr , and mutations in either subunit are associated with long QT syndrome. Although hERG1a and 1b contain identical transmembrane and C-terminal cytosolic domains, they differ in N-terminal c...

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Literature Corpus work: eac6e66c-1d46-5c25-a9ee-18b8fa47de23
DOI: 10.64898/2026.02.20.707017

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