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Article

PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.

Nature communications - 19 Sept 2024

Thon Oliver, Wang Zhihan, Schmidpeter Philipp A M, Nimigean Crina M

Abstract excerpt

The signaling lipid phosphatidylinositol-4,5-bisphosphate (PIP2) regulates many ion channels. It inhibits eukaryotic cyclic nucleotide-gated (CNG) channels while activating their relatives, the hyperpolarization-activated and cyclic nucleotide-modulated (HCN) channels. The prokaryotic SthK channel from Spirochaeta thermophila shares features with CNG and HCN channels and is an established model for this channel...

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Identifiers

PMID: 39300080
DOI: 10.1038/s41467-024-52469-1
PMCID: PMC11413322

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