Article

Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

2023-05-24

Abstract excerpt

<h4>ABSTRACT</h4> The sodium/iodide symporter (NIS) frequently shows diminished plasma membrane (PM) targeting in differentiated thyroid cancer (DTC), resulting in suboptimal radioiodide (RAI) treatment and poor prognosis. The mechanisms which govern the endocytosis of NIS away from the PM are ill-defined. Here, we challenged the hypothesis that new mechanistic understanding of NIS endocytosis would facilitate pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 519e2808-508d-5ccf-8243-f9de099e48c5
DOI: 10.1101/2023.05.22.541733

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapyDOI 10.1101/2023.05.22.541733Read

New mechanisms of radioiodide uptake revealed via a novel high throughput drug screening approach in thyroid cancerSemantic proximity Read

The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.Semantic proximity Read

The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatmentSemantic proximity Read

Sodium Iodide Symporter for Nuclear Molecular Imaging and Gene Therapy: From Bedside to Bench and BackSemantic proximity Read

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)Semantic proximity Read

The sodium iodide symporter: its pathophysiological and therapeutic implications.Semantic proximity Read

Induction of Thyroid Gene Expression and Radioiodine Uptake in Thyroid Cancer Cells by Targeting Major Signaling PathwaysSemantic proximity Read

The Biology of the Sodium Iodide Symporter and its Potential for Targeted Gene DeliverySemantic proximity Read

Sodium/Iodide Symporter Mutant V270E Causes Stunted Growth but No Cognitive Deficiency.Semantic proximity Read

A Novel SLC5A5 Variant Reveals the Crucial Role of Kinesin Light Chain 2 in Thyroid Hormonogenesis.Semantic proximity Read

NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20 <sup>high</sup> CHGA <sup>high</sup> oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidismSemantic proximity Read

The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.Semantic proximity Read