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Article

TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas.

Neuro-oncology - 1 Jan 2015

Simon Matthias, Hosen Ismail, Gousias Konstantinos, Rachakonda Sivaramakrishna, Heidenreich Barbara, Gessi Marco, Schramm Johannes, Hemminki Kari, Waha Andreas, Kumar Rajiv

Abstract excerpt

BACKGROUND: Activating somatic mutations in the promoter region of the telomerase reverse transcriptase gene (TERT) have been detected in several cancers. In this study we investigated the TERT promoter mutations and their impact on patient survival in World Health Organization grade IV glioblastoma multiforme (GBM). METHODS: The TERT core promoter region containing the previously described mutations and a common...

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Share to DNA Methylation
Share to DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Glioblastoma

Share to Kaplan-Meier Estimate

Share to Promoter Regions, Genetic

Share to Telomerase

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Source

Open in PubMed Open full text

Identifiers

PMID: 25140036
DOI: 10.1093/neuonc/nou158
PMCID: PMC4483052

Genes

TERT
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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