Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent associations of MGMT promoter methylation and TERT promoter mutation with overall survival in glioblastoma: a single-center retrospective cohort study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 22 Jun 2026

Cengiz Akın, Yıldızhan Serhat, Rakip Usame, Canbek İhsan, Boyacı Mehmet Gazi, Orhan Semiha, Aslan Adem

Abstract excerpt

BACKGROUND: Glioblastomas (World Health Organization [WHO] grade 4) are the most lethal primary brain tumors, with a median overall survival (OS) of 12-15 months despite multimodal treatment. MGMT promoter methylation and TERT promoter mutations are key prognostic biomarkers, but their combined utility remains incompletely defined. This study evaluated the prognostic effects of MGMT methylation, TERT mutations,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Glioblastoma

Share to Promoter Regions, Genetic

Share to Telomerase

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 42324391
DOI: 10.1007/s10072-026-09190-2

Genes

MGMT
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent associations of MGMT promoter methylation and TERT promoter mutation with overall survival in glioblastoma: a single-center retrospective cohort study.PMID 42324391Read ↗

Grade-Specific Influences of MGMT and TERT Genes on the Prognosis of GliomaSemantic proximity Read ↗

TERT promoter mutation as an independent prognostic marker in Glioblastoma: a prospective comparative studySemantic proximity Read ↗

The TERT promoter mutation status and MGMT promoter methylation status, combined with dichotomized MRI-derived and clinical features, predict adult primary glioblastoma survival.Semantic proximity Read ↗

The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis.Semantic proximity Read ↗

The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysisSemantic proximity Read ↗

TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas.Semantic proximity Read ↗

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes.Semantic proximity Read ↗

Human TERT promoter mutation enables survival advantage from MGMT promoter methylation in IDH1 wild-type primary glioblastoma treated by standard chemoradiotherapy.Semantic proximity Read ↗

Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patientsSemantic proximity Read ↗

A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas.Semantic proximity Read ↗

Comparative Analysis of the Prognostic Significance of IDH,TERT, EGFR and MGMT Status in Patients with Adult Non-H3-Altered Grade 4 Gliomas: A Prospective Cohort Study.Semantic proximity Read ↗

Extent, pattern, and prognostic value of MGMT promotor methylation: does it differ between glioblastoma and IDH-wildtype/TERT-mutated astrocytoma?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.