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Article

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma.

Oncotarget - 30 Jun 2015

Mosrati Mohamed Ali, Malmström Annika, Lysiak Malgorzata, Krysztofiak Adam, Hallbeck Martin, Milos Peter, Hallbeck Anna-Lotta, Bratthäll Charlotte, Strandéus Michael, Stenmark-Askmalm Marie, Söderkvist Peter

Abstract excerpt

Telomerase reverse transcriptase (TERT) activity is up-regulated in several types of tumors including glioblastoma (GBM). In the present study, 128 primary glioblastoma patients were examined for single nucleotide polymorphisms of TERT in blood and in 92 cases for TERT promoter mutations in tumors. TERT promoter mutations were observed in 86% of the tumors and of these, C228T (-124 bp upstream start codon) was...

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Identifiers

PMID: 26143636
DOI: 10.18632/oncotarget.4389
PMCID: PMC4599297

Genes

TERT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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