Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

doi:10.1093/neuonc/nov010

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Article

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

Neuro-oncology - 1 Sept 2015

Spiegl-Kreinecker Sabine, Lötsch Daniela, Ghanim Bahil, Pirker Christine, Mohr Thomas, Laaber Magdalena, Weis Serge, Olschowski Alfred, Webersinke Gerald, Pichler Josef, Berger Walter

Abstract excerpt

BACKGROUND: Expression of the telomerase reverse transcriptase (TERT) might be altered by activating mutations of the rs2853669 polymorphism within the promoter region. Here we investigate the impact of these genomic alterations on telomerase activation and dissect their prognostic potential in glioblastoma (GBM). METHODS: The respective TERT promoter region was sequenced in 126 GBM tissues and compared with...

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Identifiers

PMID: 25681309
DOI: 10.1093/neuonc/nov010
PMCID: PMC4588753

Genes

TERT
IDH1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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