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Article

TERT promoter mutations in primary and secondary glioblastomas.

Acta neuropathologica - 1 Dec 2013

Nonoguchi Naosuke, Ohta Takashi, Oh Ji-Eun, Kim Young-Ho, Kleihues Paul, Ohgaki Hiroko

Abstract excerpt

Telomerase reverse transcriptase (TERT) is up-regulated in a variety of human neoplasms. Mutations in the core promoter region of the TERT gene, which increases promoter activity, have been reported in melanomas and a variety of human neoplasms, including gliomas. In the present study, we screened for TERT promoter mutations by direct DNA sequencing in a population-based collection of 358 glioblastomas. TERT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23955565
DOI: 10.1007/s00401-013-1163-0

Genes

TERT
IDH1
EGFR

Variants

Provenance

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TERT promoter mutations in primary and secondary glioblastomas.PMID 23955565Read ↗

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