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Article

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes.

Neurology - 23 Sept 2014

Labussière Marianne, Boisselier Blandine, Mokhtari Karima, Di Stefano Anna-Luisa, Rahimian Anais, Rossetto Marta, Ciccarino Pietro, Saulnier Olivier, Paterra Rosina, Marie Yannick, Finocchiaro Gaetano, Sanson Marc

Abstract excerpt

OBJECTIVE: To identify the prognostic significance of TERT promoter mutations (TERTp-mut) and their associations with common molecular alterations in glioblastomas (GBMs). METHODS: We sequenced the TERTp-mut in DNA from 395 GBMs and analyzed the results with their respective histology, genetic profile (IDH1 mutation, EGFR amplification, CDKN2A homozygous deletion, loss of chromosome 10, TP53 mutation), and...

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Identifiers

PMID: 25150284
DOI: 10.1212/WNL.0000000000000814

Genes

EGFR
TERT
IDH1
MGMT

Provenance

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